Carotid intimamedia thickness cimt measured by bmode. The association between carotid intima media thickness cimt and cardiovascular disease is well established. Carotid intimamedia thickness cimt and carotid lumen diameter cld are strong indicators of cardiovascular event risk and stenosis severity, respectively. Ultrasound software tool measures carotid intimamedia. We aimed to 1 investigate the reproducibility of aimt in a populationderived cohort of infants. Determination of intima media thickness of common carotid artery was performed with hewlett packard sonos 5 500, using automated computer software medicasoft. If a cimt shows increased thickness in the inner layers of the carotid artery, you may be at risk for cardiovascular disease. Pdf carotid intimamedia thickness measurement through. We assessed the relation between cimt change and events in individuals at high cardiovascular risk. The link has not been established between glucose and cimt. Measurements of carotid intima media thickness in non. Carotid intima media thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al.
Intimamedia thickness imt, also called intimal medial thickness, is a measurement of the thickness of tunica intima and tunica media, the innermost two layers of the wall of an artery. Carotid intimamedia thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al. A single measurement of cimt and plaque assessment improves predictions of risk of cardiovascular disease,1,2 and accaha guidelines3 support the use of cimt and plaque measurement for cardiovascular risk stratification with a class iia recommendation ie, evidence. The morquio a cohort n 12 was 58% male and 42% female table 1. The carotid imt can be simply, noninvasively, and reproducibly measured through bmode. Carotid intimamedia thickness cimt has been shown to predict cardiovascular cv risk in multiple large studies. Evaluation of carotid intimamedia thickness imt using. A total of 60 hypercholesterolemic patients were enrolled. We observed an increase in intima media thickness of 0. Validation of an opensource tool for measuring carotid lumen. Measurements of carotid intima media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Rheumatoid arthritis ra patients have a higher chance of adverse cardiovascular events due to accelerated atherosclerosis. Abnormally increased carotid intima mediathickness and. Intimamedia thickness imt determined by bmode ultrasonography is comparable to the thickness of intimamedia complexes as determined by histologic examination.
Methods and results from 31 cohorts with two cimt scans total n 89070 on average 3. Second, mean and standard deviation sd agerelated equations were. We performed this study to evaluate the feasibility and accuracy of the newly developed korean software ks for measurement of the carotid intima media thickness imt. Reference intervals for common carotid intimamedia. Automated measurement of intimamedia thickness of carotid. Intima media thickness segmentation using weighted graph based active contour technique.
Physical manifestations of atherosclerosis may begin in early life, particularly in the abdominal aorta. The national cholesterol education program adult treatment panel iii identified imt as a method to. Evaluation of a new carotid intimamedia thickness measurement by. Measurement of the abdominal aortic intima media thickness by external ultrasound is a noninvasive methodology for quantifying the extent and severity of early. Carotid intima media thickness imt is a cvd risk factor, thus the aim of the study was to determine if an association between dietary p, especially food additive phosphate fap, intake, and imt exists. Carotid intimamedia thickness imt, an indicator of atherosclerosis and coronary heart disease chd. Intimamedia thickness segmentation using weighted graph. The carotid intima media thickness imt is a widely used surrogate marker for atherosclerosis worldwide. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive con. Carotid intimamedia thickness cimt to assess drug efficacy. Cca intima media thickness imt and circulation inflammation markers in patients with dd.
Rangasamy college of technology, tiruchengode, tamil nadu, india 2department of computer science and engineering, knowledge institute of technology, salem, tamil nadu, india abstract. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intimamedia thickness nejm group. Carotid intimamedia thickness and circulation markers of. The aim of this study was to evaluate the presence of common carotid artery cca intima media thickness imt and circulation inflammation markers in patients with dd. There are a few studies demonstrating an increase in intima media thickness imt of the common carotid artery cca after radiotherapy, especially in head and neck cancers.
Carotid artery intimamedia thickness, distensibility and. Is intimamedia thickness a predictor for cardiovascular. The carotid intimamedia thickness test cimt is a measure used to diagnose the extent of carotid atherosclerotic vascular disease. Growing evidence indicates that depressive disorders dds are an important risk factor for atherosclerosis. Common carotid intimamedia thickness and risk of stroke and. However, it is important to acknowledge that a positive effect of a drug on cimt is not necessarily translated into clinical benefit e. Common carotid artery intima media thickness ccimt is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease cvd. Carotid intimamedial thickness measured on multiple ultrasound. Ashokkumar l1, rajendran p2 1department of computer science and engineering, k. Ultrasound software tool measures carotid intimamedia thickness. Mean common carotid intima media thickness ccimt in relation to the number of risk factors rfs ie, body mass index, systolic blood pressure, triglyceride level, and lowdensity lipoprotein cholesterol level present, by sex. Comparison between carotid plaque and carotid intimamedia. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.
Currently, a new automated ultrasound software, based on radio frequency, called rfqimt technology,proved to be a useful method for assessing subclinical atherosclerosis with the measurement of the intima media thickness imt in carotid arteries. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and mean. Adult carotid intimamedia thickness, dietary fats, and. The purpose of this study was to investigate the interobserver variability of manual and also of computer software measurements of imt. Correlation of carotid intima media thickness with disease. So, what can we takeaway from these two studies looking at intima media thickness. Details regarding the control and nonmorquio mps cohorts have been published 11, 12. The objective of this study was to evaluate the correlation between articular and carotid ultrasound data and laboratory and clinical variables in patients with. With modern ultrasound scanners, imt can be easily and quickly assessed in clinical routine as well as in clinical and epidemiological research. Carotid intimamedia thickness test cimt cedarssinai. Reference intervals ris of carotid intima media thickness cimt from large healthy population are still lacking in latin america. Stiffness parameters, intima media thickness and early atherosclerosis in systemic lupus erythematosus patients show all authors. Medline, embase, scopus, and cochrane databases were searched from inception through 2009 for original research reporting.
Accordingly, several carotid intima media thickness measurements as well as plaque were related to established cardiovascular risk factors. Spectral doppler and automated softwareguided ultrasound. Intimamedia thickness of carotid artery and aortic pulse. Predictive value for cardiovascular events of common. The interactive opensource software described here, cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis. Carotid intima media thickness reference intervals for a. Cardiovascular risk factors and increased carotid intima. The automated softwareguided ultrasound assessment of. Background carotid intimamedia thickness imt is increasingly used as a. Predictive value for cardiovascular events of common carotid intima. Carotid intima media thickness measurement through semiautomated detection software and analysis of vascular walls. Extendedrelease niacin or ezetimibe and carotid intimamedia. Medline, embase, scopus, and cochrane databases were searched from inception through 2009 for original.
However, measurement of intimamedia thickness imt in the artery is. Prediction of clinical cardiovascular events with carotid intima. The aim of this study was to determine cimt ris in a cohort of 1012 healthy subjects from argentina. Usefulness of the semiautomated edgedetection software. Extendedrelease niacin or ezetimibe and carotid intima.
Genoa, italy, equipped with 712 mhz linear transducer and the automated software guided technique radiofrequencyquality intima media thickness in realtime qimt, esaote, maastricht, holland. The aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images. Intima media thickness imt, flowmediated dilation fmd of the brachial artery, and nitroglycerinemediated dilation. Jun 12, 2008 the aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images. Intimamedia thickness an overview sciencedirect topics. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made. Association of dietary pattern with carotid intima media. Carotid intima media thickness and its relations with the complications in patients with type 1 diabetes mellitus tip 1 diyabetes mellituslu hastalarda karotis intima media kal. Dec 12, 20 t1 ecgbased frame selection and curvaturebased roi detection for measuring carotid intima media thickness. Carotid intima media thickness imt is as an indicator of atherosclerosis, and manual measurement of imt manual imt is the most applied method to assess atherosclerosis. We studied the associations between the thickness of the. Measurement of the carotid intimamedia thickness enables arterial wall thickening to.
Reproducibility of aortic intimamedia thickness in. The final step in the analysis is the automatic transfer of these results into a mysql database. The measurement is usually made by external ultrasound and occasionally by internal, invasive ultrasound catheters. Aims carotid intima media thickness cimt predicts cardiovascular cvd events, but the predictive value of cimt change is debated. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intima media thickness nejm group. Reference intervals for common carotid intimamedia thickness. Carotid intima media thickness test a carotid intima media thickness test cimt is used to determine the extent of plaque buildup in the walls of the arteries supplying blood to the head. We aimed to investigate the change of cimt in prediabetes and type2 dm patients compared to subjects with normal glucose metabolism ngm. Citeseerx intimamedia thickness of the common carotid. Pdf measurement of the carotid intima, media and intima. This study was conducted to examine the effects of age and gender on cimt and cutoff values for cimt in different age groups. To enhance diagnostic effectiveness, an ultrasound software tool has been developed that can measure the thickness of the intima media layers of the carotid artery, for assessing an asymptomatic patients risk of developing cardiovascular disease. However, the accuracy of imt measurement depends on technical skill and the mechanical resolution of each ultrasonographic device.
Since there is no evidence demonstrating the relationship between dietary patterns and subclinical atherosclerosis in children and adolescents, we aimed to examine the association between dietary patterns and carotid intima media thickness cimt in children and adolescents with overweight and obesity. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and. Mar 17, 2020 morquio a carotid intima media thickness. The association between common carotid intima media thickness and incident myocardial infarction and stroke was evaluated by use of a logistic regression model. Stiffness parameters, intimamedia thickness and early. Carotid intimamedia thickness cimt is probably the most commonly used marker for atherosclerotic disease as an alternative for cardiovascular morbidity and mortality.
Cimt has been frequently utilized in clinical trials to test the efficacy of cardiovascular drugs. A method for determining the intima media thickness of the near andor far wall of a blood vessel according to claim 1, including inputting into the computer a database of the intima media thickness, and possibly the presence of plaque combined with patient information consisting of some or all, but not limited to, age, gender, typical. The authors performed a randomized controlled trial and noted that when the dietary distribution of fats met the recommended intake, there was a reduction in aortic intima media thickness and greater aortic distensibility. Limited information is currently available about whether carotid intima media thickness imt correlates with the degree of disease activity in spondyloarthritis. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive control subjects and investigated the relations of these variables to atherosclerotic risk factors methods using bmode ultrasonography, we compared carotid artery intima media thickness and plaque. Article information, pdf download for intimamedia thickness. The test measures the thickness of the inner two layers of the carotid arterythe intima and media and alerts physicians to any. At the heart of the system is computer software developed by nasas jet propulsion laboratory. Carotid intimamedia thickness in diabetics and hypertensive. Increased coronary intima media thickness cimt has been associated with adverse cardiovascular outcomes, as have increased glucose levels. Measurements of carotid intimamedia thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events.
Intimamedia thickness of brachial artery, vascular. Simply select your manager software from the list below and click on download. The cimt was determined as the average of three measurements in each common. Recently, a newly developed software allows semiautomatic measurement of mean imt auto imt. This study aimed to compare the feasibility and reproducibility of manual imt and auto imt measurement in. Evaluation of a new carotid intimamedia thickness measurement. Jan 27, 2015 the commercially available semiautomatic intimamedia thickness measurement software math 3. Biochemistry parameters were examined by routine methods. Design crosssectional study child health checkpoint, nested within a prospective cohort study, the longitudinal.
Ecgbased frame selection and curvaturebased roi detection. Intimal thickening is one of the first signs of atherosclerosis and can be measured with cimt. The upper limit of normal for the mean carotid intima media thickness ranged from 0. Assessment of intimamedia thickness of carotid arteries. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made mean or. Carotid ultrasonography was performed by a mylab 70 scanner esaote. Relationship between blood glucose and carotid intima. Carotid intimamedia thickness in subjects with no cardiovascular. Prediction of clinical cardiovascular events with carotid. Analyses were performed with common carotid intima media thickness used as a continuous variable per sd and as a categorized variable based on quintile cutoff points of the. Background the combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. Carotid intimamedia thickness and its relations with the. Us6817982b2 method, apparatus, and product for accurately. We invite you to download a 14day fully functional trial version of cardiovascular.
Atherosclerosis is the major cause of the morbidity and mortality in type 1 diabetes mellitus dm. Carotidartery intima and media thickness as a risk factor. We have developed dicombased software that measures cimt. Intimamedia thickness imt provides a surrogate end point of cardiovascular outcomes in. Aortic intima media thickness measured by transabdominal ultrasound aimt is an intermediate phenotype of cardiovascular risk. First, inter and intraobserver correlations were assessed for the. Effect of rosuvastatin on progression of carotid intimamedia. Objectives to describe a wellestablished marker of cardiovascular risk, carotid intimamedia thickness imt and related measures artery distensibility and elasticity in children aged 1112 years old and midlife adults, and examine associations within parentchild dyads. Dr bots reported receiving study grants for studies on carotid intima media thickness andor honoraria for professional input on carotid intima media thickness issues from astrazeneca, icelandic heart foundation, organon, pfizer, the netherlands heart foundation, the netherlands organisation for health research and development, servier, and. Carotid intimamedia thickness and plaque in borderline. Intima media thickness imt is widely measured for the evaluation of early atherosclerosis of the carotid artery. The commercially available semiautomatic intimamedia thickness measurement software math 3. Carotid intima media thickness cimt increases in patients with adult type2 diabetes mellitus dm and is used for early detection of macrovascular complications. Carotid intimamedia thickness and plaque in cardiovascular.
The carotid intima media thickness was assessed in 8 subjects 64 men and 74 women aged 2079 years whose age and sex were homogeneously distributed. The result of this injury can be severe and lifethreatening. Pdf carotid intimamedia thickness for atherosclerosis. The objective of this study was to assess if there is any correlation of duration and disease activity of rheumatoid arthritis with carotid intima media thickness cimt, an efficient. Measurements were performed on a ge vivid 3 ultrasound scanner. Jcm free fulltext natural history of atherosclerosis. This plugin helps in extracting the intima media thickness imt of the far wall of the common carotid artery from the. Carotid intima media thickness imt is increasingly used as a surrogate and intermediate end point of early atherosclerosis.
The difference in intima media thickness between diabetics and controls and between hypertensive patients and controls, adjusted for age, was 0. Intima media thickness imt determined by bmode ultrasonography is comparable to the thickness of intima media complexes as determined by histologic examination. Intima media thickness imt is a marker of subclinical atherosclerosis asymptomatic organ damage and should be evaluated in every asymptomatic adult or hypertensive patient at moderate risk for cardiovascular disease. N2 carotid intima media thickness cimt measurement is a sensitive, and highly reproducible technique for cardiovascular risk stratification. Intima media thickness imt has been proposed to be a morphological criterion of atherosclerosis. The commercially available semiautomatic intima media thickness measurement software math 3. Measurements of carotid intima media thickness in noninvasive. The test measures the thickness of the inner two layers of the carotid arterythe intima and mediaand alerts physicians to any thickening when patients are still asymptomatic. A suitable marker for atherosclerosis, however, should meet several criteria before it can be validly used. Evaluation of a new carotid intimamedia thickness measurement by bmode ultrasonography using an innovative measurement software, intimascope. Reproducibility of aortic intimamedia thickness in infants. Carotid averimt measurement using the new intimascope software may provide a more precise and. The interpretation of ccimt values has been hampered by the absence of reference values, however.
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